To Explore the Network Pharmacological Mechanism of Weiling Decoction in the Treatment of Metabolism-related Fatty Liver Disease
Objective:To investigate the mechanism of Weiling Decoction in the treatment of metabolism-related fatty liver disease(MAFLD).Methods:The active components of Weiling Decoction were collected by TCMSP and Uniprot database,and the gene names of the target were corrected,Disease targets of MAFLD were extracted from GeneCards,DisGeNET and OMIM databases,drug and disease targets were imported into Venny2.1 online software to obtain common targets,and drug-active components-drug target interaction network was constructed using Cytoscape 3.9.1 software.Using STRING database to map protein interaction networks online,The GO function and KEGG pathway enrichment of common targets were analyzed using Metascape database.Results:A total of 158 active ingredients of Weiling Decoction were collected,quercetin,naringenin and kaempferol are potential core components in the treatment of MAFLD.After screening,121 targets were identified for the treatment of MAFLD,it involves key targets PTGS2,ESR1,AR,PPARG,etc.Conclusion:Several components of Weiling Decoction have therapeutic activity for MAFLD,and play their roles through multi-target and multi-pathway.
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