TYK2(tyrosine kinase 2),as a member of the Janus kinase family,plays an important role in the regulation of cytokines such as IL-12,IL-23,and type Ⅰ IFN.Due to the low selectivity and adverse reactions of JAK inhibitors,the development of targeted TYK2 protein inhibitors is gradually receiving attention from researchers.Starting from the structural characteristics of TYK2 protein,this article introduces substrate competitive inhibitors targeting the TYK2 kinase domain(JH1),conformational inhibitors targeting the pseudokinase domain(JH2),and TYK2 degradation agents,providing new references for future research on TYK2 inhibitors.
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