小分子CD73抑制剂研究进展
Research Progress on CD73 Small Molecule Inhibitors
高琦 1谢欣 1虞林玉2
作者信息
- 1. 赣南医科大学,江西 赣州 341000
- 2. 赣南医科大学第一附属医院,江西 赣州 341000
- 折叠
摘要
腺苷可通过激活效应细胞上的腺苷受体介导免疫抑制,促进肿瘤细胞免疫逃逸.CD73 是人体内腺苷生物转化与代谢的关键酶,抑制CD73,调控CD73-腺苷-腺苷受体信号轴,能够有效抑制肿瘤进展.本文简单介绍CD73 功能和作用机制,回顾2013 年至今,文献报道的具有抗肿瘤作用的小分子CD73抑制剂.
Abstract
Adenosine can mediate immunosuppression by activating adenosine receptors on effector cells and promote immune escape in tumor cells.CD73 is a key enzyme in the biotransformation and metabolism of adenosine in the human body,which can effectively inhibit tumor progression by inhibiting CD73 and regulating the CD73-adenosine-adenosine receptor signaling axis.This article briefly introduces the function and mechanism of action of CD73,and reviews the small molecule inhibitors of CD73 with antitumor effects reported in the literature since 2013.
关键词
CD73/腺苷/肿瘤/免疫治疗Key words
CD73/adenosine/tumors/immunotherapy引用本文复制引用
基金项目
江西省研究生创新专项(YC2022-S968)
出版年
2024
NETL
NSTL
万方数据