Research Progress on CD73 Small Molecule Inhibitors
Adenosine can mediate immunosuppression by activating adenosine receptors on effector cells and promote immune escape in tumor cells.CD73 is a key enzyme in the biotransformation and metabolism of adenosine in the human body,which can effectively inhibit tumor progression by inhibiting CD73 and regulating the CD73-adenosine-adenosine receptor signaling axis.This article briefly introduces the function and mechanism of action of CD73,and reviews the small molecule inhibitors of CD73 with antitumor effects reported in the literature since 2013.
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