Determination of Related Substances in 2-Methylacryloyl Chloride as Key Raw Material of Bicalutamide by Gas Chromatography
A gas chromatography method was established to determine three impurities(2-methacrylic acid,2-neneneba methacrylic anhydride,benzyl trichloride)in 2-methacryloyl chloride.The chromatographic conditions were as follows:the detector was FID detector,the chromatographic column was DB-1 quartz capillary column,the sampling method was direct injection,and the temperature programmed method was used for determination.The results showed that the main component and three impurities had a good linear relationship between concentration and peak area within a specific concentration range,and the average recoveries of the three impurities were 99.6%,103.9%,and 100.1%,respectively.This method is simple to operate,has strong specificity,high sensitivity and accuracy,good linearity and durability,and can accurately and quickly determine the content of related substances in 2-methylacryloyl chloride.
gas chromatographybicalutamide2-methylacryloyl chloriderelated substances
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