气相色谱法测定比卡鲁胺关键原料2-甲基丙烯酰氯中的有关物质
Determination of Related Substances in 2-Methylacryloyl Chloride as Key Raw Material of Bicalutamide by Gas Chromatography
唐婷婷 1白玮丽 2姚彤 2刘梦婷 1常梦茹 1许瑞波1
作者信息
- 1. 江苏海洋大学药学院,江苏 连云港 222005
- 2. 连云港杰瑞药业有限公司,江苏 连云港 222006
- 折叠
摘要
建立一种气相色谱法,测定 2-甲基丙烯酰氯中 3 个杂质(2-甲基丙烯酸、2-甲基丙烯酸酐、三氯苄),色谱条件为:检测器为 FID 检测器,色谱柱采用 DB-1 石英毛细管色谱柱,进样方式为直接进样,采用程序升温的方式进行测定.结果表明,主成分及 3个杂质在特定浓度范围内,浓度和峰面积线性关系良好,3个杂质回收率平均值分别为99.6%、103.9%、100.1%.本方法操作简便,专属性强,灵敏度、准确度高,线性、耐用性良好,可以准确、快速地测定2-甲基丙烯酰氯中有关物质的含量.
Abstract
A gas chromatography method was established to determine three impurities(2-methacrylic acid,2-neneneba methacrylic anhydride,benzyl trichloride)in 2-methacryloyl chloride.The chromatographic conditions were as follows:the detector was FID detector,the chromatographic column was DB-1 quartz capillary column,the sampling method was direct injection,and the temperature programmed method was used for determination.The results showed that the main component and three impurities had a good linear relationship between concentration and peak area within a specific concentration range,and the average recoveries of the three impurities were 99.6%,103.9%,and 100.1%,respectively.This method is simple to operate,has strong specificity,high sensitivity and accuracy,good linearity and durability,and can accurately and quickly determine the content of related substances in 2-methylacryloyl chloride.
关键词
气相色谱法/比卡鲁胺/2-甲基丙烯酰氯/有关物质Key words
gas chromatography/bicalutamide/2-methylacryloyl chloride/related substances引用本文复制引用
出版年
2024
NETL
NSTL
万方数据