LC-MS/MS Liquid Chromatography-Mass Spectrometry Method for the Determination of 22 Illegal Chemical Drugs in Herbal Tea
Triple quadrupole liquid chromatography mass spectrometry was used to establish an analytical method for rapid screening and confirmation of 22 chemical drugs including acetaminophen in herbal tea.The samples were extracted with acetonitrile and then separated on an ACQUITY UPLC BEH C18 column(1.7 μm,2.1×100 mm).The separation was followed by detection and quantification using LabSolutions software.The 22 target additives demonstrated good linearity in the concentration range of 1 μg/L to 100 μg/L,with correlation coefficients(r2)greater than 0.99.The average recoveries at three spiking levels were in the range of 74.2%to 108.4%,with relative standard deviations(RSDs)below 6.0%.The detection limits ranged from 0.1 μg/L to 1.5 μg/L,and the quantification limits ranged from 0.3 μg/L to 5.0 μg/L.This method offers advantages in terms of speed,accuracy,sensitivity,and the ability to simultaneously screen and quantitate illegal additives in herbal tea,making it suitable for the rapid screening and confirmation of illegal additives in herbal tea products.
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