摘要
含氧杂环化合物广泛存在于天然产物中,在医药、食品等领域有广泛研究及应用,是天然活性物质的重要组成部分.本研究利用磷酸催化剂作用于 α,β-不饱和酮类化合物,催化关环,利用迈克尔加成机理得到十三元含氧杂环化合物.本文在以 6-庚炔-1-醇为起始原料经过烷基化、戴斯马丁氧化、witting反应、迈克尔加成等一系列的条件温和、操作简单的反应成功合成了含氧杂环化合物.为含氧杂环化合物的人工合成提供了一定的参考.
Abstract
Oxygen-containing heterocyclic compounds are widely existed in natural products,which have been widely studied and applied in the fields of medicine,food and so on,and are important components of natural active substances.In this study,we used phosphoric acid catalyst to act on α,β-unsaturated ketones to catalyse the ring closure,and obtained thirteen-membered oxygen-containing heterocyclic compounds by Michael addition mechanism.In this paper,the oxygenated heterocyclic compounds were successfully synthesised after a series of mild and simple reactions,including alkylation,Desmartin oxidation,witting reaction and Michael addition,using 6-heptyn-1-ol as the starting material.It provides a certain reference for the synthetic synthesis of oxygen-containing heterocyclic compounds.
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