Network Pharmacology of Ginseng in Treating Doxorubicin Induced Cardiotoxicity
Objective:In this study,the active ingredients of ginseng and their corresponding targets and the targets of doxorubicin induced cardiotoxicity were selected by network pharmacology,and the mechanism of ginseng in the treatment of doxorubicin induced cardiotoxicity was explored by combining the potential targets of ginseng in the treatment of doxorubicin induced cardiotoxicity with GO and KEGG pathway analysis.Methods:The active ingredients and their targets of ginseng and doxorubicin induced cardiotoxicity targets were obtained by TCMSP,GeneCards and pharmGKB databases.The obtained ginseng targets were venn analyzed with doxorubicin induced cardiotoxicity targets to obtain intersection targets.The obtained intersection targets were imported into STRING database to construct PPI network of ginseng therapeutic doxorubicin induced cardiotoxicity target protein,and then the intersection targets were imported into DAVID database for GO analysis and KEGG signaling pathway analysis.Results:There were 17 active ingredients and 114 targets of ginseng,and 532 targets of doxorubicin-induced cardiotoxicity.PPI network analysis showed 5 core targets of ginseng in the treatment of doxorubicin-induced cardiotoxicity,including AKT1,CASP3,PTGS2,TNF and BCL2.GO enrichment analysis yielded 155 items of biological process,which mainly focused on positive regulation of apoptotic process,response to lipopolysaccharide,epithelial cell apoptosis process,and positive regulation of neuron apoptotic process;9 items of cellular component,which mainly focused on cytosol,cytoplasm,plasma membrane,and nucleus;27 items of molecular function,which focused on protein binding,identical protein binding,heme binding,and enzyme binding.The results of KEGG pathway enrichment analysis showed that 87 pathways were contained,which mainly involved pathways including Lipid and atherosclerosis,Pathways in cancer,and AGE-RAGE signaling pathway in diabetic complications.Conclusion:The mechanism of ginseng in treating adriamycin cardiotoxicity may be through multiple targets and pathways.
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