Research Progress on Chiral Resolution of(R,S)-1-phenylethanol by Immobilized Lipase
(R,S)-1-phenylethanol is an important intermediate in drug synthesis and fine chemicals,and the intermediate can be asymmetrically catalyzed by immobilized lipase to obtain optically pure 1-phenylethanol.In this paper,the latest progress from three aspects of lipase type,solvent engineering,immobilization technique about the chiral preparation of(R,S)-1-phenylethanol via immobilized lipase has been reviewed,and we point out the problems to be urgently solved and propose some ideas to solve the problems in order to provide a little inspiration and reference for the chiral resolution of(R,S)-1-phenylethanol by immobilized lipase in the future.
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