Synthesis of Nitrogen-containing Heterocyclic Compounds Containing Pyrazolone and Maleimide Structural Units
Pyrazolone ring is an important structural core with antibacterial,antipyretic,analgesic and other biological activities,and pyrazolone and its derivatives have anti-inflammatory and anticancer effects.Maleimide skeleton is an important structural unit in a wide range of drugs,natural products,functional materials,and bioactive molecules.In addition,maleimide skeleton is also a key structural unit in various drug molecules and natural products.This article synthesized nitrogen-containing heterocyclic compounds containing pyrazolone and maleimide structural units using pyrazolone olefins and maleimide olefins as substrates,and screened and optimized the different experimental conditions of the synthesized products to obtain the best reaction conditions.The results showed that under the catalytic action of 20 mol%4-dimethylaminopyridine using dichloromethane as the reaction solvent,a high yield product could be obtained under the reaction condition of a ratio of 1/1.5 between maleimide olefin and pyrazolone olefin.At the same time,the reaction time for synthesizing the target product was shortened,and the target product was efficiently synthesized,laying the foundation for further investigation of the universality of the reaction.
NETL
NSTL
万方数据
