Under normal pH conditions,lysosomes can effectively digest and degrade damaged organelles and biomolecules,and play an important role in cellular digestive autophagy;abnormal lysosomal pH leads to inactivation or impairment of hydrolytic enzymes in lysosomes,which may affect the fusion of lysosomes with autophago-somes,leading to accumulation of autophagosomes and impaired autophagic flux.Therefore,lysosomal pH homeostasis is essential for understanding and studying the autophagy.
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