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心脉通胶囊质量标准研究

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目的:统一并提高心脉通胶囊的质量标准.方法:采用薄层色谱鉴别法(TLC)检验决明子和槐米;采用高效液相色谱法(HPLC)测定阿魏酸、葛根素的含量.结果:TLC法斑点清晰,分离度好,专属性强.阿魏酸、葛根素在各自范围内线性关系良好(r≥0.999),阿魏酸平均回收率为100.3%,RSD=2.0%(n=6),葛根素平均回收率为99.0%,RSD=0.4%(n=6).结论:本实验建立的质量标准科学、全面、方法可行,可用于心脉通胶囊的质量控制.
Study on Quality Standard for Xinmaitong Capsule
Objective:Unify and improve the quality standard of xinmaitong capsule.Methods:Using thin layer chromatography(TLC)for identification of Cassiae semen and Sophorae flos,and the contents of ferulic acid and puerarin were determined by high-performance liquid chromatography chromatography(HPLC).Results:The TLC spots were clear,the resolution was good,and the specificity was strong.The linear relationship between ferulic acid and puerarin is good within their respective ranges(r≥0.999).The average recovery rate of ferulic acid is 100.3%,RSD=2.0%(n=6),and the average recovery rate of puerarin is 99.0%,RSD=0.4%(n=6).Conclusion:The quality standard established in this experiment are scientific,comprehensive,and feasible,which can be used for the quality control of xinmaitong capsule.

xinmaitong capsulecassiae semensophorae flosferulic acidpuerarin

王影超、刘兴鹏、周青、廖敏、陈凤

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贵州省食品药品检验所,贵州 贵阳 550001

心脉通胶囊 决明子 槐米 阿魏酸 葛根素

2022年度国家药品标准制修订研究课题

2022Z024

2024

广东化工
广东省石油化工研究院

广东化工

影响因子:0.288
ISSN:1007-1865
年,卷(期):2024.51(12)