Mechanism of Anti-inflammatory Effect of Microctis Folium Based on Network Pharmacology
Study the anti-inflammatory mechanism of Microctis Folium based on network pharmacology methods.Using the TCMSP database and SEA database to collect the active ingredients and corresponding targets,screening anti-inflammatory targets from the GeneCards database,mapping the target genes corresponding to the ingredients and disease genes,and obtaining intersecting anti-inflammatory targets.The intersection targets were imported into the STRING database,and the results were visualized and analyzed by Cytoscape 3.9.1 software to construct the PPI network and obtain the key anti-inflammatory targets.DAVID 6.8 database was used to perform GO and KEGG enrichment analysis of key anti-inflammatory targets.Research has found that Microctis Folium may pass through quercetin,kaempferol,isorhamnetin,β-sitosterol act on targets such as TP53,AKT1,JUN,TNF,EGFR,and IL6 to regulate multiple signaling pathways and exert anti-inflammatory effects.
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