Protective Effects of Polysaccharide from Actinidia Chinensis Planch on Alcoholic Liver Injury in Mice
Objective:Exploring the protective effect of polysaccharide from Actinidia Chinensis Planch on alcoholic liver injury(ALI)model mice.Method:Ultrasound was used to extract polysaccharides from Actinidia chinensis root.Sixty healthy male Kunming mice were randomly divided into six groups:blank control group,model group,positive control group,low,medium and high dose groups of polysaccharide from Actinidia Chinensis Planch.Except for the blank group,all other groups of mice were continuously gavaged with 56° Red Star Erguotou wine for 15 days.The acute alcoholic liver injury model was replicated and killed.The serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),triglyceride(TG),total cholesterol(TC),superoxide dismutase(SOD),Glutathione peroxidase(GSH-Px),Malondialdehyde(MDA)level and tumor necrosis factor-α(TNF-))and Interleukin-6(IL-6)content in liver tissue were measured.Calculate the mouse liver index,and observe pathological sections of liver tissue.Results:The experimental results showed that compared with the model group,the levels of serum AST,ALT,TG,and TC in the different concentration groups of polysaccharides from Actinidia chinensis root were significantly reduced(P＜0.05);The levels of SOD and GSH in the liver increased significantly(P＜0.05);IL-6,TNF-α and MDA concentration decreased(P＜0.05);The pathological changes of the liver were significantly improved.Conclusion:polysaccharide from Actinidia Chinensis Planch can alleviate liver damage caused by rapid and excessive alcohol consumption,and their mechanism may be related to their antioxidant effects.
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