首页|高分子材料在《药剂学》实验改革中的应用——以PLGA为例

高分子材料在《药剂学》实验改革中的应用——以PLGA为例

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本文探讨了将聚乳酸-羟基乙酸共聚物(PLGA)引入药剂学实验课程的教学改革.PLGA具有良好的生物相容性和可降解性,广泛应用于药物递送系统.本研究以白藜芦醇为模型药物,通过反溶剂沉淀法制备了白藜芦醇PLGA纳米粒(Res-PLGA-NPs),并对其粒径、Zeta电位、包封率和载药量等进行了表征.实验结果表明,Res-PLGA-NPs具有粒径小、分布均匀、稳定性良好的特点,有效提高了白藜芦醇的水溶性和稳定性.通过此实验,学生能够深入理解高分子材料在药剂学领域的应用,提升实践技能和创新能力.
Application of Polymer Materials in the Reform of Pharmaceutical Experiments:A Case Study of PLGA
This study investigates the integration of poly(lactic-co-glycolic acid)(PLGA)into pharmaceutical sciences experiments,focusing on its application in drug delivery systems.PLGA,with its excellent biocompatibility and degradability,is widely used in this field.Utilizing resveratrol as a model drug,resveratrol-loaded PLGA nanoparticles(Res-PLGA-NPs)were prepared via a reverse solvent precipitation method and characterized for particle size,Zeta potential,entrapment efficiency,and drug loading.The results demonstrated that Res-PLGA-NPs exhibited small particle size,uniform distribution,and good stability,effectively improving the water solubility and stability of resveratrol.This experiment allows students to gain a deeper understanding of the application of polymer materials in pharmaceutical sciences,enhancing their practical skills and fostering innovation.

poly(lactic-co-glycolic acid)(PLGA)pharmaceutical sciencesexperimental teachingresveratrolnanoparticles

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遵义医科大学珠海校区,广东 珠海 519041

聚乳酸-羟基乙酸共聚物(PLGA) 药剂学 实验教学 白藜芦醇 纳米粒

2024

广东化工
广东省石油化工研究院

广东化工

影响因子:0.288
ISSN:1007-1865
年,卷(期):2024.51(13)