Research on the Extraction and Preparation Process of External Cough Suppressant Granules
Objective:To investigate the extraction and preparation process of exogenous cough granules.Methods:By adopting orthogonal experimental design,with the concentration of prim-O-glucosylcimifugin and the yield of dry extract as evaluation indicators.The factors such as the amount of water added,extraction time,and extraction frequency were investigated respectively to optimize the extraction process of Waigan Zhike Granules;with the angle of repose,forming rate and dissolution rate as indicators,the extract density,types of excipients and proportion of excipients were investigated to optimize the best forming process.Results:The optimal extraction process was 8 times the amount of water,heated and refluxed for 3 times,each time for 1 h.The optimal molding process was a relative density of 1.25(80℃)for thick paste,lactose and starch as excipients,and extract∶lactose∶starch=1∶2.5∶1.5.Conclusion:The preferred process is stable,reasonable and feasible.
Waigan Zhicough Granulesorthogonal experimentCimicifuga extractextraction processpreparation process
万方数据
维普
