Inverse Synthesis Analysis and Cross Coupling Reaction Design of 4-Methylbiphenyl
The traditional verification experiments mostly were conducted by following the specific experimental procedures,which are not conducive to the cultivation of students'innovation ability.This paper starts from inverse synthesis analysis,guides students to analyze the target product and design synthesis routes individually.When conduct the experiments,students were divided into two groups to synthesize target products by Kumada and Suzuki coupling reaction respectively.By comparing the experimental conditions and product yields,students were able to fully grasp the characteristics of the two types of cross-coupling reactions.Finally,students were assessed by writing a report as a scientific article to cultivate their basic ability of writing scientific research papers.This experiment is oriented to scientific research thinking and focuses on learning two types of cross-coupling reactions.Through this experiment,students can understand and complete a basic scientific research process,which is conducive to cultivating comprehensive and innovative talents with high scientific research literacy.
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