Study on the Preparation Process of Reaumuria Soongorica Ointment
Objective:To study the optimal preparation method of Reaumuria Soongorica ointment and determine the best preparation process.Method:Firstly,the active ingredients of Reaumuria Soongorica were extracted by ultrasonic extraction method,and the extract was concentrated.Then,the evaluation indicators such as appearance uniformity,spreadability,heat and cold resistance,and centrifugal stability were used to investigate the optimal ratios of oil,water and oil-water phase,as well as the best emulsification temperature,through single-factor experiments.On this basis,the optimal ointment matrix ratio and emulsification temperature were selected by L9(34)orthogonal experiment.Finally,the Reaumuria soongorica ointment with 5％drug load was prepared,and the optimal preparation process of red sand ointment was determined by L9(34)orthogonal experiment and formulation optimization.Results:The best preparation process of Reaumuria soongorica ointment was as follows:drug-loading amount of 5％;oil-water ratio of 1∶2.5;oil phase:stearic acid(9.40％),white petroleum(7.00％),Span-80(3.50％),lanolin(4.70％),liquid paraffin(4.70％),ethylparaben(0.15％);water phase:triethanolamine(3.60％),glycerol(10.70％),concentrated aqueous extract of red sand and distilled water(57.10％).The two phases were separately heated to 80 ℃ in a water bath,and then the water phase was slowly added to the oil phase with rapid stirring to obtain an O/W type Reaumuria soongorica ointment.Conclusions:The Reaumuria soongorica ointment with stable physicochemical properties,good heat and cold resistance,uniform appearance and pleasant skin feeling was prepared,which laid the foundation for further application of Reaumuria soongorica ointment in the treatment of dermatitis and eczema.
万方数据
维普
