Study on the Drying Method of Residual Water after Sterilization-In-Place of Liquid Preparation System
Objective:To establish a drying method for the residual water after Sterilization-In-Place(SIP)of the liquid dispensing system(including microporous filter),to realize the storage of equipment in a dry condition,eliminate the production of microbial/bacterial endotoxins,and ensure the quality of the liquid after filling.Methods:Compressed air was used to dry the residual water of the liquid dispensing system(including microporous filter)after SIP by controlling the temperature and pressure of purging.Results:The results indicate that the liquid dispensing system(including microporous filter)can be effectively and quickly purged and dried by heating the compressed air to 70℃～80℃,keeping the pressure at 0.2 MPa and adjusting the exhaust valve to the maximum opening.Conclusion:A drying method that can be used in practical work for liquid dispensing system after SIP is established,which can eliminate residual water and effectively control microorganisms in the liquid dispensing system.
liquid dispensing systemmicroporous filtersterilization-In-Placeresidual watercompressed air
万方数据
维普
