Study of a Dual-loaded Drug Controlled Release System for the Treatment of Hyperlipidemia
Microspheres were prepared by emulsion solvent volatilization,and the encapsulation rate of two drugs,SC-PP-MS was optimized,and the optimal preparation scheme was verified.The microspheres were produced at(4.32±2.42)μm,PDI at(0.216±0.076),and Zeta potential(-17.23±1.87)mV.The release period was 25 d and the spike release was small.After fitting,the SIV and CAV release curves met the Ritger-Peppas release equation,which met 0.45＜n＜0.89,and the drug release in the microsphere was PEG-PLGA skeleton dissolution and drug diffusion.In vitro release results showed that at 25 d,SIV was 88.48%and 91.65%,respectively,and the process of sudden release was smooth.
万方数据
维普
