Improvement of Preparation Process Chiral Intermediate Ethyl(R)-4-Cyano-3-hydroxybutyrate
A green and environmentally friendly chiral intermediate of atorvastatin(R)-4-cyano-3-hydroxybutyrate was developed.Double immobilized enzyme is used in this process,4-chloroacetyl ethyl ester as the starting material was first reduced by ADH enzyme to get(S)-(-)-chloro-3-hydroxy-butyrate ethyl ester,and then(R)-4-cyano-3-hydroxy-butyrate ethyl ester was prepared by reaction with sodium hydrocyanic under the catalysis of dehalogenase enzyme.The preparation process is simple,the reaction conditions are mild,the atomic economy is high,and the total yield can reach more than 85%.
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