Carbapenem-resistant Klebsiella Pneumoniae Resistance Mechanisms and Therapeutic Advances
Klebsiella pneumoniae are Gram-negative bacilli often found in the human upper respiratory and intestinal tracts,and are important conditionally pathogenic and medically acquired infections.With the overuse of carbapenem antibiotics,the clinical isolation rate of carbapenem-resistant Klebsiella pneumoniae(CRKP)has increased dramatically.CRKP are highly resistant to carbapenem antibiotics,which have been referred to as the"last line of defense against bacteria".The resistance mechanism of this group of bacteria to carbapenems mainly involves carbapenemase production,high production of Amp C or ESBLS enzyme combined with OMP deletion or under-expression,active efflux pumps and biofilm,etc.In recent years,carbapenem-resistant pathogens have been recognized as the most effective antibiotics in the world.In recent years,the emergence and spread of drug-resistant pathogens have led to the decreasing efficacy of antimicrobial drugs,and the rapid spread of"superbugs"around the world is particularly worrisome,which greatly increases the difficulty of our treatment.Therefore,this article reviews the drug resistance mechanism and therapeutic progress of CRKP,hoping to provide reference for the prevention,transmission control and treatment of CRKP infection,and to provide a scientific basis for the drug resistance mechanism of CRKP.
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