摘要
消化道肿瘤是全球癌症相关死亡的主要原因之一.环境、饮食和生活方式因素以及家族史是消化道肿瘤最重要的危险因素.尽管目前的肿瘤治疗方法(包括手术、化疗和放疗)有所改善,但由于诊断延迟、复发和药物副作用,晚期消化道肿瘤患者的生活质量仍然较差.因此,迫切需要寻找新的治疗策略来提高患者的治疗效果和生存率.白藜芦醇(Res)具有多种有价值的药理作用,包括抗氧化、抗炎、抗癌、抗菌和心血管保护作用,迄今为止,Res在预防和治疗消化道肿瘤中的多种抗癌分子机制涉及其作用的多种途径,包括氧化应激、细胞增殖和细胞凋亡.
Abstract
Digestive tract tumors are one of the leading causes of cancer-related deaths worldwide.Environmental,dietary and lifestyle factors,as well as family history,are the most important risk factors for GI tumors.Despite improvements in current oncological treatments(including surgery,chemotherapy and radiotherapy),the quality of life of patients with advanced GI tumors remains poor due to delayed diagnosis,recurrence and drug side effects.Therefore,there is an urgent need to find new therapeutic strategies to improve patient outcomes and survival.Resveratrol(Res)has a variety of valuable pharmacological effects including antioxidant,anti-inflammatory,anticancer,antimicrobial,and cardiovascular protective effects,and to date,multiple anticancer molecular mechanisms of Res in the prevention and treatment of gastrointestinal tumors involve a variety of pathways of its action,including oxidative stress,cell proliferation,and apoptosis.
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