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基于高分辨质谱的中药学本科实验课程教学探索

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中药制剂是由多种中药配伍组成的,是一个复杂的分子体系,其分析鉴定工作存在较大难度.高效液相色谱与高分辨质谱联用系统(HPLC-HRMS)在中药复方的定性研究中发挥着重要作用.本论文通过探索将高分辨液相色谱质谱联用系统应用到中药学本科生实验教学实践中,建立了对中药制剂参松养心胶囊中 5 种特征性成分进行鉴定的实验教学方法.使学生了解高分辨质谱在中药制剂分析和鉴定中的重要应用,开阔了本校中药学专业本科生的科研视野,提高了学生对仪器分析的理解,对培养高素质高水平的药学本科生起到了积极作用.
Exploration of Undergraduate Experimental Course Teaching in Traditional Chinese Medicine Base on High Resolution Mass Spectrometry
The chemistry composition of traditional Chinese medicine(TCM)preparations which are composed of various TCM is complex.It is difficult to analysis or identification complex TCM ingredients.The qualitative research of TCM is greatly enhanced by the use of high performance liquid chromatography and high resolution mass spectrometry(HPLC-HRMS).This paper explores the application of a high-resolution liquid chromatography-mass spectrometry system in the experimental teaching practice of undergraduate Chinese medicine students,and establishes an experimental teaching method for identifying five characteristic components in the TCM preparation Shensong Yangxin Capsules.By utilizing high-resolution mass spectrometry,students can gain a deeper understanding of the key role of such technology in the analysis and identification of TCM preparations.This could expand the scientific research perspective of TCM undergraduates at our institution,enhance their comprehension of instrumental analysis,and contribute to cultivate high-quality and high-level pharmaceutical undergraduate students.

high resolution mass spectrometryexperimental teachinginstrumental analysisanalysis of traditional Chinese medicine preparationscomposition identification

李雯、王林、李焕勇、何乔

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暨南大学,广东 广州 510632

高分辨质谱 实验教学 仪器分析 中药制剂分析 成分鉴定

2024

广东化工
广东省石油化工研究院

广东化工

影响因子:0.288
ISSN:1007-1865
年,卷(期):2024.51(18)