Integrating Frontline Research Achievements into Organic Chemistry Laboratory Instruction:Preparation and Applications of Grignard Reagents under Mechanochemical Conditions
Grignard reagents are among the most widely used carbon nucleophiles in organic synthesis,and the development of efficient and environmentally friendly synthesis methods has been a key focus in chemistry.Traditional laboratory preparation methods often involve complex procedures and significant safety risks.To address these issues,this study introduces ball milling technology as a green alternative synthesis approach.Specifically,the method involves directly placing alkyl halides and magnesium metal into a ball mill under air conditions,using the continuous mechanical force applied during the milling process to drive the reaction and efficiently prepare solid-state Grignard reagents under solvent-free conditions.Compared to conventional methods,this technique not only simplifies procedural steps but also significantly enhances synthesis efficiency and reduces the use of hazardous solvents.This experiment is designed to provide students with a deeper understanding of the Grignard reaction mechanism and familiarize them with cutting-edge mechanochemical synthesis techniques,thereby increasing their knowledge of relevant disciplines,improving their research skills,and fostering their innovative capabilities in scientific research.
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