一种亚胺键的壳聚糖基水凝胶的设计与合成
Design and Synthesis of a Chitosan-based Hydrogels Based on Imine Bond
罗小艳 1黄诗雅 1郑楚楚 1章莉娟1
作者信息
- 1. 华南理工大学 化学与化工学院 广东省绿色化学产品技术重点实验室,广东 广州 510640
- 折叠
摘要
设计合成了羧甲基壳聚糖(CMC)与二醛基原酸酯(CHO-OE-CHO)单体.羧甲基壳聚糖(CMC)单体极大地改善了壳聚糖的水溶性,并保留了大量氨基参与水凝胶的形成.两端均为醛基的原酸酯单体(CHO-OE-CHO)具有较强的酸敏感特性,能在弱酸性条件下水解.两种凝胶因子CMC与CHO-OE-CHO在水中能自发形成亚胺键,构建CHO-OE-CHO/CMC水凝胶网络.采用傅里叶红外光谱表征水凝胶的分子结构,显示水凝胶的形成与亚胺键自发成键有关.扫描电镜的测试结果表明,CHO-OE-CHO/CMC水凝胶呈三维网状结构,具有较多的孔隙,在医用敷料领域具有一定的应用潜质.
Abstract
We designed and synthesized two monomers of carboxymethyl chitosan(CMC)and ortho ester dialdehyde(CHO-OE-CHO).CMC greatly improved the water solubility,and retained a large number of amino groups to participate in the formation of hydrogel.CHO-OE-CHO had acid-sensitivity and could be hydrolyzed under acidic conditions.Two gel factors,CMC and CHO-OE-CHO,could construct CHO-OE-CHO/CMC hydrogel network spontaneously by imine bonds.FT-IR was used to characterize the structure of hydrogel,which proved that the formation of hydrogel was related to the spontaneous bonding of imine bonds.The image of SEM showed that the CHO-OE-CHO/CMC hydrogel had three-dimensional network structure with many gaps,which has potential application for medical dressings.
关键词
水凝胶/医用敷料/亚胺键/壳聚糖/原酸酯键Key words
hydrogel/medical dressing/imine bond/chitosan/ortho ester bond引用本文复制引用
出版年
2024
NETL
NSTL
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