Optimization of Extraction Technology of Yiyibaijiang Decoction by Box-Benhnken Response Surface Methodology and Information Entropy Theory
Objective:To optimization of Extraction Technology of Yiyibaijiang decoction by Box-Benhnken Response Surface Methodology and Information Entropy Theory.Methods:On the basis of single factor experiment,response surface method combined with information entropy theory was used to calculate the comprehensive index(M),with the amount of water,extraction time and extraction times as the important influencing factors,and the contents of chlorogenic acid,Salvianolic acid B,paeonol and the paste rate were used as evaluation indexes.In order to optimize the extraction technology of Yiyibaijiang decoction.Results:The optimized extraction process was as follows:the decoction pieces were added 9.8 times of water,soaked for 118 min,extracted 2 times,validation experiment showed that the predicted total comprehensive score was within 5%of the actual measured value,indicating a good correlation.Conclusionsl:The response surface methodology model is accurate and can predict the three components and the yield of the cream,it can provide a reference for large-scale production of Yiyibaijiang decoction.
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