头孢地尼颗粒中二硫化二苯并噻唑的检测
Detection of Dibenzothiazole Disulfide in Cefdinir Granules
崔姣 1陆媛1
作者信息
- 1. 广州白云山天心制药股份有限公司,广东 广州 510300
- 折叠
摘要
目的:建立儿童用药头孢地尼颗粒中二硫化二苯并噻唑的检测方法.方法:采用高效液相色谱法,以甲醇∶水=80∶20为流动相,柱温35℃,检测波长 275 nm.结果:在检测范围内,二硫化二苯并噻唑有良好的线性关系(r=0.9994),精密度良好(RSD为 2.7%,n=6),平均回收率为99.4%(RSD为 2.0%,n=9),在 25℃24 小时内溶液稳定性良好.结论:高效液相色谱法作为检测方法,灵敏度高,专属性强,可用于头孢地尼颗粒中二硫化二苯并噻唑的测定.
Abstract
Objective:To establish an analysis method for the determination of dibenzothiazole disulfide in cefdinirgraunles.Methods:HPLC method was used with methol:water=80:20 as mobile phase,column temperature of 35℃,detection wavelength of 275 nm.Results:Within the detection range,dibenzothiazole disulfide had a good linear relationship(r=0.9994),good precision(RSD of 2.7%,n=6),average recovery of 99.4%(RSD of 2.0%,n=9),and good solution stability at 25℃for 24 hours.Conclusion:As a detection method,HPLC has high sensitivity and strong specificity,and can be used for the determination of dibenzothiazole disulfide in cefdinir granules.
关键词
头孢地尼颗粒/二硫化二苯并噻唑/高效液相色谱法Key words
cefdinir granules/dibenzothiazole disulfide/HPLC引用本文复制引用
出版年
2024
NETL
NSTL
万方数据