A Study on the Efficacy of a Combination of Yeast Lysate Products and Peptide in Serum
In this study,a serum with multifunctional skin efficacy was prepared by compounding specific levels of bifida ferment lysate,palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7.The skin efficacy of the serum was evaluated by constructing a mouse macrophage inflammation model,HaCaT human immortalized epidermal cell scratch experiment,zebrafish eln1,eln2 gene relative expression test and facial anti-wrinkle efficacy human evaluation experiment.The results of the anti-inflammatory efficacy experiment showed that 0.1％～0.3％concentration of the serum can significantly reduce the release of IL-6 inflammatory factors,showing soothing and anti-inflammatory efficacy;the results of the in vitro cell scratch assessments showed that,0.2％concentration of the serum can promote the migration of the human epidermal cells within 48 h,revealing the efficacy of the skin barrier repair;zebrafish eln1,eln2 gene relative expression test data show that 0.25％or more concentration of the serum can significantly increase the relative expression of elastin genes,showing firming effect.An 8-week human evaluation data of the anti-wrinkle efficacy of the serum was scientifically assessed using the Primos CR instrument,and it was found that the serum could significantly improve the appearance of fine lines and under-eye wrinkles.
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