Study on Preparation Technology of Classic Famous Fang Yi Huang Decotion Granules
Objective:To study the best preparation of Yihuang tang granules and process parameters.Methods:Yihuangn tang granules were prepared by dry granulation.By using the compressibility,solubility,and hygroscopicity of particles as indicators,the types of excipients are screened.Optimize the types of excipients and flavor correction agents used in the granulation process,confirm the optimal preparation process for granules,and conduct prescription validation experiments.Results:The preferred excipients were maltodextrin.The parameters of the dry granulator were as follows:the pressing thickness was 0.2 mm～1.0mm,the thickness range was±0.3mm,the hydraulic pressure was 60 bar～160 bar,the spiral feed speed was 40-130 rpm,the extrusion roller speed was 5 rpm～30 rpm,and the whole grain speed was 80 rpm～190 rpm.The roller temperature shall not exceed 35℃,and the upper and lower line was 0.1～4.0.Crude grain and fine powder re-treatment,over 14/40 mesh sieve,to make a suitable hardness,color consistent particles.The process validation results of 3 batches showed that the yield of the preferred granulation method were high.Conclusion:The preferred preparation process of Yihuang Tang granules were stable and reliable,and can be used in the subsequent industrial production of peach soup particles.
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