To Explore the Mechanism of the Main Chemical Components of Laoxianghuang on the Improvement of Enteritis Based on Network Pharmacology
Objective:To explore the mechanism of Laoxanghuang in the prevention and treatment of inflammatory bowel disease by network pharmacology and molecular docking.Methods:The active constituents and potential targets of Laoxianghuang were screened in TCMSP database and Swiss Target Prediction database through literature retrieval.The coincidental targets of the active ingredient and IBD were obtained by GeneCard database and Venn diagram,and the PPI network was constructed by String database and Cytoscape software to screen the core components and targets.Use David database and R language for KEGG analysis;Finally,Autodock vina software was used to perform molecular docking between the core target and the active ingredient.Results:There were 20 active components in the eighth year of the laoxiang Huang,among which 5 core ingredients were Chrysocerin,Kaempferol,7-hydroxycoumarin,5,7-Dimethoxycoumarin and Nomilin.The 10 core targets were EGFR,SRC,AKT1,etc.It is mainly involved in PI3K-AKT,MAPK,EGFR and other signaling pathways.The results of molecular docking verified that the key active ingredient could spontaneously bind to the core target.Conclusion:Laoxiang Huang may regulate immune inflammation,cell proliferation,differentiation and apoptosis through multiple components,multiple targets and multiple pathways,thereby reducing inflammatory response and repairing intestinal barrier,and achieving the treatment of inflammatory bowel disease.This provides a theoretical basis for the further development and application of Laoxiang Huang in intestinal diseases.
laoxianghuanginflammatory bowel diseasedual use of food and medicinePI3K-AKTchrysoeriol7-hydroxycoumarin
NETL
NSTL
万方数据
