New Course Exploration on"Natural Medicinal Chemistry"Experiment under the Background of"Double Carbon":Preparation of Indenone Compounds by Photo-initiated Radical
Under the key background of the"two-carbon"strategic goal,this paper carries out a new exploration of the experiment of"Natural Pharmaceutical Chemistry",so that students can understand the concept of green drug synthesis,enhance learning interest and improve teaching quality.The purpose of this course is to educate students in the design of acyl radical formation by ultraviolet light in the absence of metal catalyst,and then cascade cyclation reaction with free radical receptor alkyne to prepare 2,3-diphenyl-5-methyl-1-indone,an important natural drug derivative in natural pharmaceutical chemistry.The product was separated and purified by column chromatography,the structure of the product was identified by nuclear magnetic resonance,and the reaction mechanism was explored by the control experiment.During the experiment,through explaining the theory and application of photocatalytic free radical reaction,students can understand the concept of green chemistry,master the principle of applying what they have learned,improve their interest in learning,cultivate their ability to solve practical professional problems,and achieve the purpose of improving the teaching quality.
chemistry of natural productsexperiment and explorationteaching reform
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