首页|NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

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Photothermal and photodynamic therapies(PTT/PDT)hold promise for localized tumor treatment,yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune activation.Ad-dressing these challenges,we present a novel near-infrared(NIR)-triggered RNS nanoreactor(PBNO-Ce6)to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer(TNBC).The designed PBNO-Ce6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS produc-tion through NIR-induced concurrent NO release and ROS generation.This not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses,protecting mice from tumor rechallenge.Our in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic T lymphocytes and a 62%decrease in regulatory T cells in comparison to the control PB-Ce6(Prussian Blue nanoparticles loaded with Chlorin e6),marking a substantial improvement over traditional PTT/PDT.As such,the PBNO-Ce6 nanoreactor repre-sents a transformative approach for improving outcomes in TNBC and potentially other malignancies affected by similar barriers.

photothermal therapyphotodynamic therapynitric oxidereactive nitrogen speciestriple-negative breast cancerimmune responsenanoreactor

Ziqing Xu、Yakun Kang、Jie Zhang、Jiajia Tang、Hanyao Sun、Yang Li、Doudou He、Xuan Sha、Yuxia Tang、Ziyi Fu、Feiyun Wu、Shouju Wang

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Laboratory of Molecular Imaging,Department of Radiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China

Department of Breast Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China

Department of Women&Children Research Center,The First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,China

National Natural science Foundation of ChinaNational Natural science Foundation of ChinaNational Natural science Foundation of ChinaJiangsu Province Natural Science Foundation of ChinaDouble First Class Foundation of China Pharmaceutical University

823720198202203482173327BK20200032CPUQNJC22_03

2024

10.29026/oea.2024.240013

光电进展(英文版)

光电进展(英文版)

EI
ISSN：
年,卷(期)：2024.7(6)