首页|High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor

High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor

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The specific detection of tumor markers is crucial in early tumor screening and subsequent treatment processes.To ac-curately distinguish the signal response caused by trace markers,the high demodulation resolution of the sensor is nec-essary.In this paper,we propose a dual-wavelength fiber laser sensing system enhanced with microwave photonics de-modulation technology to achieve high-resolution tumor marker detection.This sensing system can simultaneously per-form spectral wavelength-domain and frequency-domain analyses.Experimental results demonstrate that this system's refractive index(RI)sensitivity reaches 1083 nm/RIU by wavelength analysis and-1902 GHz/RIU by frequency analysis,with ideal detection resolutions of 1.85×10-5 RIU and 5.26×10-8 RIU,respectively.Compared with traditional wavelength domain analysis,the demodulation resolution is improved by three orders of magnitude,based on the same sensing structure.To validate its biosensing performance,carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5)is selected as the detection target.Experimental results show that the improved sensing system has a limit of detection(LOD)of 0.076 ng/mL and a detection resolution of 0.008 ng/mL.Experimental results obtained from human serum samples are consistent with clinical data,highlighting the strong clinical application potential of the proposed sens-ing system and analysis method.

optical fiber sensoroptical fiber lasermicrowave photonics demodulationhigh-resolution detectiontumor marker detection

Jie Hu、Weihao Lin、Liyang Shao、Chenlong Xue、Fang Zhao、Dongrui Xiao、Yang Ran、Yue Meng、Panpan He、Zhiguang Yu、Jinna Chen、Perry Ping Shum

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Department of Electronic and Electrical Engineering,Southern University of Science and Technology,Shenzhen 518055,China

School of Electrical Information Engineering,Hunan Institute of Technology,Hengyang 421002,China

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications,Institute of Photonics Technology,Jinan University,Guangzhou 510632,China

Department of Clinical Laboratory,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 511436,China

Medcaptain Medical Technology Co.,Ltd.,Shenzhen 518055,China

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2024

10.29026/oea.2024.240105

光电进展(英文版)

光电进展(英文版)

EI
ISSN：
年,卷(期)：2024.7(12)