穿心莲内酯生物合成与调控的研究进展
Research Progress of the Biosynthesis and Regulation of Andrographolide
张龙 1顾艳 2李静宇 2徐世强 2孙铭阳 2胡学博 3王继华1
作者信息
- 1. 华中农业大学植物科学技术学院,湖北 武汉 430070;广东省农作物遗传改良重点实验室/广东省农业科学院作物研究所,广东 广州 510640
- 2. 广东省农作物遗传改良重点实验室/广东省农业科学院作物研究所,广东 广州 510640
- 3. 华中农业大学植物科学技术学院,湖北 武汉 430070
- 折叠
摘要
穿心莲内酯是中药材穿心莲的主要活性成分,具有清热解毒、抗菌消炎、保肝利胆等功效,临床上主要用于治疗小儿肺炎和上呼吸道感染等疾病.近年来,由于环境因素长期影响、品种纯度不高以及优良品种选育工作滞后等原因,很大程度上限制了穿心莲的品质提升.在穿心莲药材质量评价中,穿心莲内酯的含量是一项非常重要的指标,通过解析穿心莲内酯生物合成的分子机制及积累规律,有助于提升穿心莲药材质量.该文综述了穿心莲内酯的生物合成途径与分子调控机制,穿心莲内酯的生物合成主要分为两大阶段,即穿心莲内酯前体的合成阶段和穿心莲内酯合成的修饰阶段,其中前体合成研究已经较为清楚,但有关穿心莲内酯合成修饰阶段的途径和关键酶的挖掘还处于空白水平,需进一步研究.通过从环境因素和栽培措施两个层面对穿心莲内酯合成积累的关键影响因子进行挖掘,有利于建立完善的高品质穿心莲种植体系.此外,对调控穿心莲内酯生物合成的研究进展进行总结和展望,可为穿心莲药材品质提升提供参考.
Abstract
Andrographolide is the main active ingredient of Andrographis paniculata,which has the functions of clearing heat and detoxifying,antibacterial and anti-inflammatory,protecting liver and improving gallbladder.It is clinically used to treat pneumonia in children and upper respiratory tract infection.In recent years,because of the influence of environmental factors for a long time,not high purity and good varieties of selective breeding work lag and so on reasons,greatly restricted the quality improvement of andrographolide.In the quality evaluation of A.paniculata,the content of andrographolide is a very important index.Analyzing the molecular mechanism and accumulation rule of andrographolide biosynthesis is helpful to improve the quality of A.paniculata.In this review,the biosynthetic pathways and regulatory molecular mechanisms of andrographolide are comprehensively discussed.The biosynthesis of andrographolide is mainly divided into two stages,including the synthesis stage of andrographolide precursor and the modification stage of andrographolide synthesis.The synthesis of precursor has been relatively clear,but the mining of the pathways and key enzymes in the modification stage of andrographolide synthesis is still at a blank,and further research is needed.Through the excavation of the key factors affecting the synthesis and accumulation of andrographolide from the two levels of environmental factors and cropping systems,it is conducive to the establishment of a perfect and high-quality A.paniculata cultivation system.In addition,the research progress on the regulation of andrographolide biosynthesis was summarized and prospected,in order to provide research reference for the improvement of A.paniculata quality.
关键词
穿心莲/穿心莲内酯/生物合成/调控/环境因素/栽培措施Key words
Andrographis paniculata/andrographolide/biosynthesis/regulation/environmental factor/cultivation measures引用本文复制引用
基金项目
广东省重点领域研发计划(2020B020221001)
广东省农科院创新基金(2024)()
出版年
2024
NETL
NSTL
万方数据