Parkinson’s disease is recognized as the world’s second largest nerve system disease, more than 2. 45 million people have already sick of our country, the influence the population health level of our country has become a major social problem. Of Parkinson’s disease pathogenesis is not clear. Based on the analysis of the disease epidemic status, risk factors, on the basis of discussing the relationship between the trace elements associated with Parkinson’s disease, and trace element profiling used for early warning and the possibility of early diagnosis of the disease.