MRI and MRS Analysis of Bone Marrow Infiltration in Children With Acute Leukemia
Objective To evaluate the MRI and MRS imaging in bone marrow in children with acute leukemia during early stage of the disease, remission and relapse. Methods To study the characteristics of MRI imaging and MRS imaging in 30 children (aged 2 ~ 16 years) with acute leukemia from February 2015 to August 2016 in our hospital. 25 cases of acute lymphoblastic leukemia, 5 cases of acute non lymphocytic leukemia, 24 cases of early stage, 21 cases of chemotherapy remission group, 2 cases of recurrence group, 17 cases were in the early stage of the onset of the disease, chemotherapy remission or recurrence of MRI. 30 cases of normal children in the same age group were compared with the control group. Results During the initial onset of acute lymphoblastic leukemia, the bone marrow was reduced in the T1 signal, and STIR showed a more uniform increase in the bone marrow signal;MRS showed that the onset of the early stage of lipid peaks disappear or horizon, water peak towering. Remission of bone marrow cavity increased signal in T1 compared to the primary group STIR showed bone marrow signal;signal intensity;MRS lipid peak reproduction. Compared with the control group, there were significant differences in bone marrow FF% between the early group and the control group ( P<0. 05 ) . There was no significant difference between the two groups compared with the control group (P>0. 05). Conclusion Using bone marrow MRI and MRS as a noninvasive tool for evaluation of bone marrow status and prognosis in children with acute leukemia has a high value.
magnetic resonance spectroscopyacute leukemiabone marrow
NETL
NSTL
万方数据
维普
