儿童急性白血病骨髓浸润的MRI与MRS分析
MRI and MRS Analysis of Bone Marrow Infiltration in Children With Acute Leukemia
王静石 1于泓 1孟醒 1陈裕 2严志汉2
作者信息
- 1. 大连市妇女儿童医疗中心，辽宁 大连 116033
- 2. 温州医科大学附属第二医院，浙江 温州 325000
- 折叠
摘要
目的：研究儿童急性白血病在发病初期、化疗缓解期及复发期骨髓MRI及MRS成像。方法研究大连市妇女儿童医疗中心2015年2月至2016年8月间30例儿童(2~16岁)急性白血病患者的MRI平扫及MRS成像特征。急性淋巴细胞白血病25例,急性非淋巴细胞白血病5例；早期组24例,化疗缓解组21例,复发组2例,17例分别在发病初期、化疗缓解期或复发期行MRI检查。对照组为30例同年龄段正常儿童志愿者。结果急淋初始发病时骨髓在T1信号减低, STIR 示骨髓信号较均匀增高； MRS 显示发病初期组脂峰消失或地平,水峰高耸。化疗缓解组骨髓腔信号在T1较初发组信号增高； STIR示骨髓信号减低； MRS脂峰复现。早期组与化疗缓解组比较、早期组与对照组之间骨髓FF%有显著性差异( P<0.05),而化疗缓解组与对照组比较,无显著性差异(P >0.05)。结论骨髓MRI及MRS作为一种无创性的检查工具,对儿童急性白血病骨髓状态及评价预后具有价值。
Abstract
Objective To evaluate the MRI and MRS imaging in bone marrow in children with acute leukemia during early stage of the disease, remission and relapse. Methods To study the characteristics of MRI imaging and MRS imaging in 30 children (aged 2 ~ 16 years) with acute leukemia from February 2015 to August 2016 in our hospital. 25 cases of acute lymphoblastic leukemia, 5 cases of acute non lymphocytic leukemia, 24 cases of early stage, 21 cases of chemotherapy remission group, 2 cases of recurrence group, 17 cases were in the early stage of the onset of the disease, chemotherapy remission or recurrence of MRI. 30 cases of normal children in the same age group were compared with the control group. Results During the initial onset of acute lymphoblastic leukemia, the bone marrow was reduced in the T1 signal, and STIR showed a more uniform increase in the bone marrow signal;MRS showed that the onset of the early stage of lipid peaks disappear or horizon, water peak towering. Remission of bone marrow cavity increased signal in T1 compared to the primary group STIR showed bone marrow signal;signal intensity;MRS lipid peak reproduction. Compared with the control group, there were significant differences in bone marrow FF% between the early group and the control group ( P<0. 05 ) . There was no significant difference between the two groups compared with the control group (P>0. 05). Conclusion Using bone marrow MRI and MRS as a noninvasive tool for evaluation of bone marrow status and prognosis in children with acute leukemia has a high value.
关键词
磁共振波谱/急性白血病/骨髓Key words
magnetic resonance spectroscopy/acute leukemia/bone marrow引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据