首页|格列美脲与二甲双胍联合短期内强化治疗初诊2型糖尿病的疗效及安全性分析

格列美脲与二甲双胍联合短期内强化治疗初诊2型糖尿病的疗效及安全性分析

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目的:研究格列美脲与二甲双胍联合短期内强化治疗初诊2型糖尿病的疗效及安全性。方法以天津市武清区河西务医院2015年1月—2016年11月初诊2型糖尿病患者106例随机分两组。 A组采用常规饮食、运动等干预,并口服格列美脲治疗,B组在A组基础上联合二甲双胍治疗,共治疗12周。比较两组患者低血糖、肝肾和胃肠不良反应发生率;血糖达标时间;施行治疗前和施行治疗后患者血糖水平、胰岛素分泌指数、胰岛素抵抗指数的差异。结果两组患者低血糖、肝肾和胃肠不良反应发生率无显著差异, P>0.05; B组血糖达标时间短于A组, P<0.05;施行治疗前两组血糖水平、胰岛素分泌指数、胰岛素抵抗指数比较无显著差异, P>0.05;施行治疗后B组血糖水平、胰岛素分泌指数、胰岛素抵抗指数改善幅度更大, P<0.05。结论格列美脲与二甲双胍联合短期内强化治疗初诊2型糖尿病的疗效及安全性高,可有效改善患者血糖水平和胰岛素分泌情况,低血糖风险低,安全可靠,值得推广。
GlennBeauty Urea With Metformin in the Short Term to Strengthen Both the Efficacy and Safety Analysis for Type 2 Diabetes
Objective To study the Glenn beauty urea with metformin in the short term to strengthen both the efficacy and safety of type 2 diabetes. Methods From January 2015 to November 2016 first diagnosis in patients with type 2 diabetes, 106 cases were randomly divided into two groups. Group A with normal diet and exercise intervention, such as beauty and oral Glenn urea treatment, B group on the basis of A set of combined therapy with metformin, A total of 12 weeks of treatment. Compare two groups of patients with low blood sugar, liver and kidney and the incidence of gastrointestinal adverse reactions;Blood glucose control is at the time; Performed before and after treatment patients ' blood sugar levels, differences in insulin secretion, insulin resistance index. Results Two groups of patients with low blood&nbsp;sugar, liver and kidney, and no significant difference in incidence of gastrointestinal adverse reactions, P>0. 05; Blood glucose control is at target group B was shorter than group A, P < 0. 05; Before implementation of treatment two groups of blood glucose, insulin secretion, insulin resistance index was no significant difference, P > 0. 05; Implementation of group B blood glucose levels after treatment, insulin secretion, insulin resistance index has improved more, P<0. 05 ) . Conclusion Craig beauty urea with metformin in the short term to strengthen both the efficacy and safety of type 2 diabetes, which can effectively improve the patients' blood sugar levels and insulin secretion, low risk of hypoglycemia, safe and reliable, is worth promoting.

glenn beautiful ureametforminthe short-term intensie treatmentfirst diagnosis of type 2 diabetescurative effectsecurity

武淑俊

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天津市武清区河西务医院,天津 301714

格列美脲 二甲双胍 短期内强化治疗 初诊2型糖尿病 疗效 安全性

2017

广东微量元素科学
广东省科学技术情报研究所 广州地区微量元素与健康研究会 广州市微量元素研究所

广东微量元素科学

影响因子:0.355
ISSN:1006-446X
年,卷(期):2017.24(1)
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