Study on the Pharmacokinetics and Pharmacodynamics of Vancomycin in Population
Objective To study the difference of the pharmacokinetic parameters between the groups and to optimize the pharmacodynamics of the patients.Methods In our hospital from January 2015 to December 2015 were 268 cases, according to the divided into young group and the old age group, 134 cases in each group, the pharmacokinetics and pharmacodynamics of group medicine formula optimization, analysis of differences between patients with the above indexes.Results There were significant differences between the young group and the old group in the pharmacokinetic parameters of each group (P<0.05).Conclusion The curative effect of vancomycin to patients infected by drug treatment is effective, obvious killing effect on Gram positive bacteria, the pharmacokinetic and pharmacodynamic study of population pharmacokinetics showed that AUC24/MIC can use as indicators of norvancomycin, and to guide the clinical medication effect is significant, worthy of clinical application.
NETL
NSTL
万方数据
维普
