Study on Hypoglycemic Effect and Safety of Insulin Combined with Shah Glenn Dean
Objective To assess the efficacy and safety of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes(T2DM) on basic of insulin.Methods 50 patients with poorly controlled T2DM on basic of insulin were added on saxagliptin or acarbose for (48±8) weeks.Retrospective control studies change of plasma glucose,HbA1c,MAGE and so on.Results After treatment for (48±8) weeks,the plasma glucose,HbA1c and MAGE decreased significantly in both groups(all P≤0.001).It shows more remarkable decrease in MAGE and less gastrointestinal symptoms in saxagliptin group than those of acarbose group(P=0.024).Conclusion Saxagliptin-insulin has similar effect on glucose control with acarbose-insulin in patients with T2DM,and more improvement in glucose fluctuations and lower gastrointestinal side effects than the latter.
type 2 diabetes mellitussaxagliptinacarboseglucose fluctuations
NETL
NSTL
万方数据
维普
