This study focused on the efficacy of antimicrobial peptides to corneal trauma in experimental rabbits.Three study groups were set up for the trial,including group A(bacterial antimicrobial peptide group),group B(levofloxacin group)and group C(model control group).The rabbit corneal trauma model was first established.Different treatment was applied separately and the relevant test indicators were observed.The results showed that the tear secretion of the experimental rabbits in both the bacterial antimicrobial peptide and levofloxacin treatment groups were significantly lower than that of the model control group(P<0.05).Corneal fluorescence staining on day 28 of the trial showed that deep corneal damage had been largely repaired in the rabbits's cornea of the antimicrobial peptide treatment group,which was superior to that of the levofloxacin treatment group.Compared with the model control group,the levels of pro-inflammatory factors such as IL-1,IL-8 and MMP-2 in the aqueous humor of the experimental rabbits in the antimicrobial peptide treatment group were significantly lower(P<0.05)than those in the levofloxacin treatment group.The results of the live bacterial count showed that the bacterial antimicrobial peptide inhibited ocular infections after corneal trauma significantly more than levofloxacin in experimental rabbits(P<0.05).The results of the experiment showed that the comprehensive efficacy of the antimicrobial peptide in the treatment of corneal injury in experimental rabbits was significantly better than that of levofloxacin,which provided some experimental data and theoretical basis for the application of bacterial antimicrobial peptide in the treatment of corneal injury in pets in veterinary clinics.
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