Research Progress on the Photolysis Mechanism of Pharmaceutical Agents for Animals
At the intensive farming end,active drug components and excipients that are highly sensitive to light will undergo significant degradation,affecting the quality and stability of the agents,such as tetracyclines,sulfonamides,fluoroquinolone agents.Full understanding of drugs and excipients photodegradation mechanisms and kinetics is key to product development.Reports on preventing photodegradation and enhancing the photostability of photounstable components in drug dosage forms have focused on the research of formulation and process,to assess the photodegradation of the drug product from manufacturing to application stage.This paper focuses on various photodegradation mechanisms,rate dynamics,and factors affecting the rate of photodegradation,and briefly introduces different methods to improve the photostability of photosensitive molecules,aim to provide theoretical basis and broad ideas for the research and development and application of veterinary drugs.
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