Effects of High Dosage Dietary Iron on Growth Performance and Oxidative Stress of Jejunal Mucosal in Yellow-feathered Chickens Aged 22 to 42 Days
This experiment was conducted to study the effects high dosage dietary iron ingested on growth performance and jejunal mucosal oxidative stress of Yellow-feathered chickens aged 22 to 42 days.A total of 450 22-day-old male rapidly-growing Yellow-feathered chickens were randomly divided into 3 groups with 6 replicates per group and 25 birds per replicate.The basal diets were supplemented with 0(control group),1 200 mg/kg and 2 400 mg/kg Ferrous gluconate(FG),respectively.The experimental chickens were fed and watered freely for 21 days.The results showed that there were no significant differences in average daily feed intake,average daily gain and feed to gain ratio among the three treatment groups(P＞0.05).But,the diarrhea rate of Yellow-feathered chickens in 1 200 mg/kg and 2 400 mg/kg ferrous gluconate groups was significantly higher than that in control group(P＜0.05).The activities of plasma induced nitric oxide synthase and creatine kinase and the content of malondialdehyde in jejunum mucosa of 2 400 mg/kg FG group were significantly higher than those of the control group(P＜0.05).The gene expressions of nuclear factor E2-related factor 2,caudal homologous transcription factor 2 and closed small cycloprotein-1 in jejunum tissues of 1 200 mg/kg and 2 400 mg/kg FG groups were significantly lower than those of control group(P＜0.05).In conclusion,dietary supplementation of high dose of ferrous gluconate(1 200 mg/kg to 2 400 mg/kg)has no negative effect on growth performance of Yellow-feathered chickens aged 22 to 42 days,but it induces oxidative damage of jejunum mucosa of chickens,and the degree of damage is related to the dosage of ferrous gluconate,which in turn led to a significant increase in diarrhea rates.
万方数据
维普
