摘要
蛋白激酶CK2具有组成型活化功能.目前已知CK2作用底物超过300种,涉及细胞生长、增殖、分化、凋亡及信号转导等.此外,CK2通过抑制细胞非正常凋亡而在细胞生命活动中扮演重要角色,确保细胞在炎症或病毒入侵环境下存活.该文综述了CK2的抗炎和抗病毒作用.
Abstract
Protein kinase CK2 has constitutive activation functions. More than 300 substrates for CK2 have been discovered, which are involved in cell growth, proliferation, differentiation, apoptosis, and signal transduction. In addition, CK2 plays an important role in cell life activities by inhibiting abnormal apoptosis, which ensures the cell survive under inflammatory environment or viral invasion. This article reviews the anti-inflammatory and antiviral role of CK2.
基金项目
国家自然科学基金(No.81671399)
广东省普通高校创新团队建设(No.2015KCXTD022)
广东省普通高校特色创新(No.2015KTSCX049)
东莞市国际科技合作(含港澳台)(No.201650812001)
广东医科大学建博科技创新团队(No.STIF201102)
NETL
NSTL
维普
万方数据