广东医科大学学报2024,Vol.42Issue(1) :1-9.

氧气生理学和氧毒性机制的研究进展

Oxygen physiology and mechanisms of oxygen toxicity:A review on recent developments

刘丹勇 夏正远
广东医科大学学报2024,Vol.42Issue(1) :1-9.

氧气生理学和氧毒性机制的研究进展

Oxygen physiology and mechanisms of oxygen toxicity:A review on recent developments

刘丹勇 1夏正远2
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作者信息

  • 1. 广东医科大学附属医院麻醉科,广东湛江 524000
  • 2. 广东医科大学附属医院麻醉科,广东湛江 524000;湖北省钟祥市官冲博士湾科研与转化培训平台,湖北钟祥 431913
  • 折叠

摘要

氧气对地球的生命至关重要.人类通过呼吸所获得的氧气在线粒体内被消耗,主要用于氧化磷酸化产生能量.氧气过少或过多都容易对人类产生极大的危害.氧气过少时,可导致组织器官供氧不足,出现功能障碍,严重者可致死亡;氧气过多时,机体不能消耗多余的氧气,使细胞处于高氧状态,导致大量的ROS(Reactive Oxygen Species)产生,进一步引起细胞膜和细胞器的氧化损伤导致氧毒性.虽然人体有多种氧感应机制防止器官和细胞遭受低氧和高氧诱导的氧化应激,但在给氧治疗中,尤其是老年人吸氧过程中,连续实时的个体化监测与指导仍尤为重要,应尽量在避免或减少氧毒性的同时纠正低氧血症和组织缺氧.

Abstract

Oxygen is essential to life on Earth.The oxygen obtained by human respiration is consumed within the mitochondria,mainly for oxidative phosphorylation to produce energy.Too little or too much oxygen can easily cause great harm to humans.When oxygen is too low,it can lead to insufficient oxygen supply to tissues and organs,resulting in dysfunction and death in severe cases.When there is too much Oxygen,the body cannot consume the excess oxygen,so that the cells are in a state of high oxygen,resulting in the production of a large amount of reactive oxygen species(ROS),which further causes oxidative damage to the cell membrane and organelles,leading to oxygen toxicity.Although the human body has multiple oxygen-sensing mechanisms to prevent organs and cells from suffering from hypoxia and hyperoxia-induced oxidative stress,but in oxygen therapy,especially in the process of oxygen inhalation in the elderly,continuous real-time individualized monitoring and guidance are still particularly important,in order to maximally avoid or reduce oxygen toxicity during the treatments for hypoxemia and tissue hypoxia correction.

关键词

氧气/三羧酸循环/性别/年龄/氧毒性/ROS

Key words

oxygen/tricarboxylic acid cycle/gender/age/oxygen toxicity/ROS

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基金项目

国家自然科学基金(82270306)

出版年

2024
广东医科大学学报
广东医学院

广东医科大学学报

影响因子:0.828
ISSN:1005-4057
参考文献量81
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