Hepatic fibrosis(HF)is complex pathological process that is regulated by a variety of cells,mediators,and signaling pathways,and leads to excessive deposition of extracellular matrix and collagens.Protein translational modifications(PTMs)are chemical modifications of substrates and functional groups after DNA is transcribed into mRNA and further translated into proteins.The HF process undergoes extensive PTMs.This paper reviews the role of protein phosphorylation and nitrosylation in HF.
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