老年人小腿围、HCAR与认知障碍的因果中介分析——基于CLHLS2014数据
Causal mediation analysis of Calf Circumference,HCAR and Cognitive Impairment in older adults-based on CLHLS2014 data
徐吟文 1胡填 2田晴晴 3刘洲4
作者信息
- 1. 广东医科大学附属医院康复医学科,广东湛江 524001
- 2. 揭阳市人民医院康复医学科,广东揭阳 522000
- 3. 广东医科大学医学技术学院,广东湛江 524000
- 4. 广东医科大学附属医院神经内科,广东湛江 524000
- 折叠
摘要
目的 探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用.方法 筛选2014年CLHLS数据库中的1 784例老年人数据.通过中文版简易精神状态量表(Chinese version of the brief mental state examination,cMMSE)评估认知功能.使用R软件进行数据处理和分析,Bootstrap抽样法验证中介效应.结果 校正多种协变量后,小腿围与认知障碍呈显著负相关(OR=0.951,95％CI:0.933～0.970),HCAR在其中起到中介作用(中介效应比例为0.022,95％CI:0.002～0.060).结论 小腿围与认知障碍之间存在负关联,HCAR起中介作用.该发现对预防和干预认知障碍有重要意义.
Abstract
Objective This study aims to investigate the relationship between calf circumference and cognitive impairment and to study the mediating role of the hypersensitive C-reactive protein(hs-CRP)/albumin ratio(HCAR).Methods Data in the 2014 CLHLS database were analyzed,and 1 784 study participants were finally included in this study.Cognitive function was assessed by the Chinese version of the brief mental state examination(cMMSE).Data were processed and analysed using R software,and mediating effects were verified using Bootstrap sampling.Results After correcting for multiple factors,calf circumference was significantly negatively associated with cognitive impairment(OR=0.951,95％CI:0.933-0.970),in which HCAR played a mediating role(mediating effect ratio 0.022,95％CI:0.002-0.060).Conclusion There is a negative association between calf circumference and cognitive impairment,in with HCAR plays a mediating role.This finding has important implications for the prevention and intervention of cognitive impairment.
关键词
超敏C反应蛋白/白蛋白比值/小腿围/认知障碍/中介分析/CLHLS数据库Key words
high-sensitivity C-reactive protein(hs-CRP)/albumin ratio(HCAR)/calf circumference/cognitive impairment/Mediation analysis/Chinese longitudinal healthy longevity survey(CLHLS)database引用本文复制引用
基金项目
湛江市非资助科技攻关计划(2022B01004)
广东医科大学青年培育基金(GDMUQ2021034)
出版年
2024
NETL
NSTL
万方数据