摘要
目的 探讨铁蛋白、尿酸、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)对原发性高血压患者颈动脉内膜中层厚度(CIMT)增厚的预测价值.方法 106 例原发性高血压患者分为CIMT增厚组(55 例)和正常组(51 例),比较两组铁蛋白、尿酸、Hcy、hs-CRP水平,采用logistic回归分析,并以ROC曲线评价CIMT增厚的预测价值.结果 增厚组的铁蛋白、尿酸、Hcy、hs-CRP水平均明显高于正常组(P<0.01).logistic回归分析显示铁蛋白、尿酸、Hcy、hs-CRP均是CIMT增厚的独立危险因素(P<0.05).铁蛋白、尿酸、Hcy、hs-CRP单独检测的AUC分别为 0.735、0.802、0.818、0.778,4项指标联合检测的AUC为 0.939(P<0.01).结论 铁蛋白、尿酸、Hcy、hs-CRP在CIMT增厚预测中具有一定价值,但 4种指标联合检测的预测效能最高.
Abstract
Objective To investigate the predictive value of ferritin,uric acid,homocysteine(Hcy),and hypersensitive C-reactive protein(hs-CRP)for carotid intima-media thickening(CIMT)in primary hypertension.Methods A total of 106 patients with primary hypertension were divided into thickening group(55 cases)and normal group(51 cases).Ferritin,uric acid,Hcy,and hs-CRP levels were compared between 2 groups and analyzed Logistic regression analysis.Their predictive value for CIMT was evaluated using ROC curve.Results Ferritin,uric acid,Hcy,and hs-CRP levels were higher in thickening group than in normal group(P<0.01).Logistic regression analysis showed that they were independent risk factors for CIMT(P<0.05).The AUC of ferritin,uric acid,Hcy,hs-CRP,and their combination were 0.735,0.802,0.818,0.778,and 0.939(P<0.01),respectively.Conclusion There may be some predictive value of ferritin,uric acid,Hcy,and hs-CRP for CIMT in primary hypertension,with the highest of their combined detection.
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