肝星状细胞的代谢重编程在肝纤维化发展中的研究现状
Overview of the role of metabolic reprogramming of hepatic stellate cells in liver fibrosis
武士豪 1何钰宏 1李嘉兴 2李明意3
作者信息
- 1. 广东医科大学第一临床医学院,广东 湛江 524023
- 2. 广东医科大学附属医院肝胆外科研究室,广东 湛江 524001
- 3. 广东医科大学附属医院肝胆外科,广东 湛江 524001
- 折叠
摘要
肝星状细胞在肝损伤后活化,导致肝纤维化.活化过程中,肝星状细胞发生代谢重编程,以满足其增殖和分泌细胞外基质所需的巨大能量需求.这种重编程涉及糖、脂质和蛋白质等代谢的改变.深入了解这些代谢变化有助于开发新的抗肝纤维化治疗策略,通过干预肝星状细胞的代谢重编程来抑制其活化,从而缓解肝纤维化进程.该文综述了肝纤维化发生时肝星状细胞的糖、脂质和蛋白质代谢重编程现象,并探讨了这些代谢变化在肝纤维化发展中的作用.
Abstract
Following liver injury,hepatic stellate cells become activated,a process leading to liver fibrosis.During activation,hepatic stellate cells undergo metabolic reprogramming to satisfy the enormous energy requirements necessary for their proliferation and secretion of extracellular matrix.This reprogramming entails alterations in carbohydrate,lipid,and protein metabolism.A comprehensive understanding of these metabolic alterations can aid in the development of novel anti-hepatic fibrosis therapies,aimed at mitigating liver fibrosis by targeting the metabolic reprogramming of hepatic stellate cells to inhibit their activation.In this article,we review the metabolic reprogramming of carbohydrates,lipids,and proteins in hepatic stellate cells at the onset of liver fibrosis and discuss the role of these alterations in the progression of the condition.
关键词
肝纤维化/肝星状细胞/代谢重编程Key words
liver fibrosis/hepatic stellate cells/metabolic reprogramming引用本文复制引用
出版年
2024
NETL
NSTL
万方数据