Breast cancer has become the most prevalent malignancy among women globally,with an increasing incidence rate.Traditional treatment modalities such as chemotherapy,endocrine therapy,and molecular targeted therapy have achieved certain clinical successes,but their effectiveness is severely compromised by drug resistance issues.Proteolysis Targeting Chimeric(PROTAC)technology,as an emerging protein degradation strategy,offers new possibilities for treating drug-resistant breast cancer,particularly PROTAC molecules derived from natural products exhibited great potential.This review summarized the current status and future trends of PROTAC technology in breast cancer treatment.It focuses on PROTAC research progress targeting different molecular subtypes of breast cancer,delves into the design of PROTAC molecules based on natural products,and explores their potential value in breast cancer treatment.Additionally,the review provides new insights into the prospects of marine drugs developed based on PROTAC technology in breast cancer treatment.
关键词
乳腺癌/蛋白降解靶向嵌合体/天然产物/靶点
Key words
breast cancer/proteolysis targeting chimeric/natural products/target
维普
万方数据