Objective To determine the factors that affect cognitive functions in the long-lived individuals(90 years old or above).Method We took advantage of the datasets from Chinese Longitudinal Healthy Longevity Survey 2018 for discovery and 2014 for validation purpose,respectively.The included factors covered gender,residence,lifestyle,and illness.The individuals at the age of 90 or plus were enrolled into the study and an ordered logistic regression analysis was used to assess how the factors correlate with cognitive function.Results After exclusion of those with dementia,it was found that the cognitive impairment in females was significantly higher than that in males with OR(95%CI)of 1.81(1.54-2.12).Other factors such as fruits,vegetables,tea drinking,alcohol consumption(present),exercise(present),and hypertension were negatively correlated to the cognitive impairment with OR(95%CI)of 0.71(0.58-0.87)、0.42(0.31-0.56)、0.77(0.64-0.93)、0.69(0.53-0.90)、0.44(0.36-0.55)and 0.66(0.57-0.77),all P<0.05.Diabetes and smoking exhibited no correlations with cognitive dysfunction(P>0.05).Conclusion Compared with general population,the long-lived individuals present differential responses to risk factors,such as smoking,alcoholic consumption,diabetes,and hypertension,for cognitive impairments.These findings may have potential implications in the improvement of cognitive functions and in the treatment of other common age-related diseases.
维普
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